Ocular coherence tomography (OCT) scanning of optic nerve head painlessly and rapidly quantitatively measures for the existence of prior injuries to the optic nerve. The presence of these defects is very common in MS and supports the presence of disease prior to established disability.
Quantitative somatosensory testing to determine thresholds for thermal and vibration sensitivity. This testing can demonstrate slight degrees of numbness which are not detectable by normal examination.
Color vision defects can be detected by a computer driven color blind testing system. Such minor changes are indicators of optic nerve disease which is seen in MS.
Multimodality evoked potentials use multiple visual stimuli (color, movement) rather than a single (black and white) stimulus to measure visual responses. Somatosensory evoked potentials performed by highly trained technicians are helpful for demonstrating how much injury is present in the central nervous system.
Motor evoked responses permit accurate measurement of conduction velocity in the central nervous system. Differences between two sides indicate a typical injury such as is seen in multiple sclerosis.
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